It depends on how many event points you have and what level of auto/click damage boost you use, the bonus damage from those add with damage boost ability.
So you will want something around speed = damage + X + Y, where X = % from event milestone and Y = % from ascension upgrade damage boost (a weighted average between auto and click, not their sum).
So you will want something around speed = damage + X + Y, where X = % from event milestone and Y = % from ascension upgrade damage boost (a weighted average between auto and click, not their sum).